SAT-554 Genetic Profile of Early-Onset Aldosterone-Producing Adenomas
نویسندگان
چکیده
منابع مشابه
Aldosterone-Producing Adenomas
Unilateral primary aldosteronism (PA) is a common surgically curable cause of secondary hypertension. Adrenal glands removed for unilateral PA display histological heterogeneity. Recently, gain-of-function somatic mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, and CTNNB1 have been found in 50% to 80% of aldosterone-producing adenomas (APAs). These gain-of-function mutations provide plausible mech...
متن کاملGenetic Alterations and Molecular Signatures in Aldosterone Producing Adenomas
Åkerström, T. 2016. Genetic Alterations and Molecular Signatures in Aldosterone Producing Adenomas. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1197. 49 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9517-6. Primary Aldosteronism (PA) is caused by autonomous overproduction of aldosterone. Aldosterone is necessary for fluid and ion homeosta...
متن کاملGene Expression Profile of Persistent Postoperative Hypertension Patients with Aldosterone-producing Adenomas
BACKGROUND Hypertension often persists after adrenalectomy for primary aldosteronism (PA). Many studies have analyzed the outcomes of adrenalectomy for aldosterone-producing adenomas (APA) to identify predictive factors for persistent hypertension. However, differentially expressed genes in persistent postoperative hypertension remain unknown. Our aim was to describe gene expression profile of ...
متن کاملExpression profile of serotonin4 (5-HT4) receptors in adrenocortical aldosterone-producing adenomas.
OBJECTIVE We aimed to investigate the expression profile of serotonin4 (5-HT4) receptors in adrenocortical aldosterone-producing adenoma (APA) tissues in comparison with normal adrenal cortex. DESIGN AND METHODS Total 5-HT4 receptor mRNAs were quantified by real-time quantitative polymerase chain reaction (PCR) assay, and the mRNAs encoding the 5-HT4 receptor isoforms were characterized by re...
متن کاملLocalization of the endothelin system in aldosterone-producing adenomas.
Endothelin-1 (ET-1) could play a role in the regulation of aldosterone secretion of the human adrenal gland. The presence of the endothelin-converting enzyme 1 (ECE-1) and ET-1 suggests that there is a local ET system in the adrenal cortex, but the in situ synthesis of ET-1 remains to be confirmed. The cellular distribution of the whole ET system was evaluated in 20 cases of aldosterone-produci...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2020
ISSN: 2472-1972
DOI: 10.1210/jendso/bvaa046.910